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Torin 1Chemotherapy was potentiated by E7449 and solitary agent had sizeable antitumor exercise in BRCA-deficient xenografts. Furthermore, E7449 inhibited Wnt/β-catenin signaling in colon cancer mobile lines, very likely by means of TNKS inhibition. In line with this possibility, E7449 stabilized axin and TNKS proteins causing β-catenin de-stabil